Condition Cardiovascular Disease
The Cardiovascular Inflammation Reduction Trial (CIRT) is a randomized clinical trial investigating whether taking low-dose methotrexate reduces heart attacks,
strokes, or death in people with type 2 diabetes or metabolic syndrome that
have had a heart attack or multiple coronary blockages.
Investigate whether low-dose methotrexate (LDM) will reduce rates of myocardial infarction, stroke, and cardiovascular death among stable coronary artery disease patients with type 2 diabetes or metabolic syndrome.entry and elevated hsCRP will prevent recurrent cardiovascular events.
Key Inclusion Criteria
Documented past history of myocardial infarction OR past evidence of multi-vessel coronary artery disease by angiography and history of type 2 diabetes or metabolic syndrome at time of study enrollment.
Key Exclusion Criteria
- Prior history of chronic infectious disease
- Chronic inflammatory condition
- Women of child bearing potential