Current Clinical Trials

Cardiac

• This is an international, multicenter, parallel-group, randomized, double-blind, placebo-controlled trial in patients who have been stabilized during hospitalization for acute heart failure, evaluating the effect of in-hospital initiation of dapagliflozin versus placebo on the clinical outcome of cardiovascular death or worsening heart failure.
  • Study ID: DAPA ACT HF-TIMI 68
  • Principal Investigator: Jason Go, MD
  • Sub Investigator: Puvanalingam Ayyadurai, MD, FACC
• A Randomized, Double-blind, Placebo-controlled Trial Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Participants With Established Cardiovascular Disease (VICTORION-2 PREVENT)
  • Study ID: Novartis V2P
  • Principal Investigator: Jason Go, MD
  • Sub Investigator: Puvanalingam Ayyadurai, MD, FACC
• A Randomized, Double-blind, Placebo-controlled Multicenter Study to Evaluate the Effect of Inclisiran on Preventing Major Adverse Cardiovascular Events in High-risk Primary Prevention Patients (VICTORION-1 PREVENT)
  • Study ID: Novartis V1P
  • Principal Investigator: Jason Go, MD
  • Sub Investigator: Puvanalingam Ayyadurai, MD, FACC

Gynecology

• Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer
  • STUDY ID: ECHO
  • Principal Investigator: Collette Lessard, MD

Oncology

• Blood
  • A Post-authorization Safety Study to Evaluate the Incidence of and Risk Factors for Severe and Fatal Infusion-related Reactions in Participants Treated with Daratumumab (Intravenous or Subcutaneous)
    • STUDY ID: HALO
    • Principal Investigator: Karine Darbinyan, MD
• Breast
  • TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer.
    • Study ID: CCTG MA.39
    • Principal Investigator: Grant Seeger, MD
  • Mepitel Film for the Reduction of Radiation Dermatitis in Breast Cancer Patients Undergoing Post-Mastectomy Radiation Therapy: A Randomized Phase III Clinical Trial
    • Study ID: Alliance A221803
    • Principal Investigator: Grant Seeger, MD
  • Evaluation of Lasofoxifene Combine with Abemaciclib Compared with Fulvestrant Combined with Abemaciclib in Locally Advanced or Metatstatic ER+/HR2- Breast Cancer with an ESR1 Mutation
    • STUDY ID: ELAINE 3
    • Principal Investigator: Grant Seeger, MD
• Kidney
  • Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study.
    • Study ID: Alliance A031704
    • Principal Investigator: Grant Seeger, MD
• Lung
  • This is a Phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab with SoC SBRT versus placebo with SoC SBRT in patients with unresected clinical Stage I/II lymph node-negative (T1 to T3N0M0) NSCLC.
    • Study ID: PACIFIC-4/RTOG-3515
    • Principal Investigator: Grant Seeger, MD
  • MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK).
    • Study ID: SWOG S1827
    • Principal Investigator: Grant Seeger, MD
  • Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer
    • Study ID: NRG LU008
    • Principal Investigator: Grant Seeger, MD
  • A Study of V940 Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants with Non-Small Cell Lung Cancer
    • STUDY ID: V940-002
    • Principal Investigator: Grant Seeger, MD
• Prostate
  • This phase II trial compares the effect of oxybutynin versus placebo for reducing hot flashes in men receiving androgen deprivation (hormone) therapy for the treatment of prostate cancer. Androgen deprivation therapy decreases testosterone and other androgens through medications or surgical removal of the testicles. Relative to placebo, low- or high-dose oxybutynin may reduce hot flashes in men receiving androgen deprivation therapy.
    • Study ID: Alliance A222001
    • Principal Investigator: Grant Seeger, MD
  • Parallel Phase III Randomized Trials of Genomic-Risk Stratified Unfavorable Intermediate Risk Prostate Cancer: De-Intensification and Intensification Clinical Trial Evaluation (GUIDANCE).
    • Study ID: NRG GU010
    • Principal Investigator: Grant Seeger, MD
  • Parallel Phase III Randomized Trials for High Risk Prostate Cancer Evaluating De-Intensification for Lower Genomic Risk and Intensification of Concurrent Therapy for Higher Genomic Risk With Radiation (PREDICT-RT*)
    • Study ID: NRG GU009
    • Principal Investigator: Grant Seeger, MD
  • Relugolix Versus Leuprolide in Patients With Prostate Cancer: A Randomized, Open-Label Study to Assess Major Adverse Cardiovascular Events (REPLACE-CV)
    • Study ID: Myovant REPLACE-CV
    • Principal Investigator: Grant Seeger, MD
• Supportive Care
  • A Randomized Phase III Trial of Olanzapine Versus Megestrol Acetate for Cancer-Associated Anorexia.
    • Study ID: Alliance A222004
    • Principal Investigator: Grant Seeger, MD

Biorepository

• The Biorepository for Caris Life Sciences is designed for the purpose of making quality biospecimens and associated clinical data available for research studies related to advancing precision medicine and improving care for patients.
  • Study ID: Caris Biorepository
  • Principal Investigator: Grant Seeger, MD
• The Vallania Study: A Case Control Study for the Development of Multiomics Blood Tests for Cancer Screening
  • Study ID: Freenome Vallania Study
  • Principal Investigator: Grant Seeger, MD

You can learn more about clinical trials by visiting clinicaltrials.gov, which is a database of privately and publicly funded clinical studies conducted around the world. 

Contact Us

Altru Health System, Research
1380 South Columbia Road
Grand Forks, ND 58201
Phone: 701.780.5195
Email: adagoberg@altru.org