Peripheral nerve tumors



Schwannoma of the tibial nerve in the leg
Schwannoma in the leg

Schwannoma in the leg

Schwannoma of the tibial nerve in the leg

Benign tumors can occur in nerves, muscle and bone. This illustration shows a schwannoma of the tibial nerve in the leg.

Complex nerve sheath tumor in the shape of a dumbbell
Dumbbell tumor

Dumbbell tumor

Complex nerve sheath tumor in the shape of a dumbbell

A more complex nerve sheath tumor may assume the shape of a dumbbell. This type of tumor occurs in the spine and lower abdomen and are intertwined with important nerves.

Acoustic neuroma, a benign tumor on the nerves leading from the inner ear to the brain
Acoustic neuroma (vestibular schwannoma)

Acoustic neuroma (vestibular schwannoma)

Acoustic neuroma, a benign tumor on the nerves leading from the inner ear to the brain

An acoustic neuroma (vestibular schwannoma) is a benign tumor that develops on the balance and hearing nerves leading from the inner ear to the brain. These nerves are twined together to form the vestibulocochlear nerve (eighth cranial nerve). The pressure on the nerve from the tumor may cause hearing loss and imbalance.

Peripheral nerve tumors are growths that form in or near nerves. Nerves are strands of tissue that transmit signals from the brain to the rest of the body. Peripheral nerves control muscles that allow you to walk, blink, swallow, pick things up and do other activities.

Peripheral nerve tumors can occur anywhere in the body. Most of them are benign, meaning they're not cancerous. But they can lead to pain, nerve damage and loss of function in the affected area.

Treatment usually involves surgery to remove the tumor. When the tumor can't be removed without damaging nearby healthy tissue and nerves, other treatments may be considered.

There are several types of peripheral nerve tumors. Intraneural tumors grow within nerves. Extraneural tumors press against nerves.


The symptoms of a peripheral nerve tumor develop from direct effects on the main nerve or from the tumor pressing on nearby nerves, blood vessels or tissues. As the tumor grows, it may be more likely to cause symptoms, although tumor size doesn't always determine effects.

Symptoms of peripheral nerve tumors vary depending on where the tumors are located and the tissues affected. They include:

  • Swelling or a lump under the skin.
  • Pain, tingling or numbness.
  • Weakness or a loss of function in the affected area.
  • Dizziness or a loss of balance.

When to see a doctor

See your health care provider if you have any of the symptoms listed, especially if you have a lump that grows quickly.


The spinal cord, which extends from the base of the skull to the lower back
Nervous system

Nervous system

The spinal cord, which extends from the base of the skull to the lower back

The spinal cord is housed within the spinal canal, a hollow chamber within the vertebrae (spinal canal). It extends from the base of the skull to the lower back.

It's not clear why most peripheral nerve tumors develop. Some are linked to known inherited syndromes, such as neurofibromatosis (types 1 and 2) and schwannomatosis. Others may be caused by changes in a gene.

Risk factors

Peripheral nerve tumors are more common in people who have:

  • Neurofibromatosis (types 1 and 2) and schwannomatosis. In these disorders, tumors develop on or near the nerves throughout the body. There are often multiple tumors. They can lead to a variety of symptoms depending on where they are in the body. These tumors are usually not cancerous.
  • A history of radiation treatment. A person who was exposed to radiation is at higher risk of developing peripheral nerve tumors years later.


Peripheral nerve tumors can press against nerves. This can lead to complications. Some may be permanent:

  • Numbness and weakness in the affected area.
  • Loss of function in the affected area.
  • Trouble with balance.
  • Pain.


To diagnose a peripheral nerve tumor, your health care provider will ask about your symptoms and medical history. You may undergo a general physical exam and a neurological exam. Several tests may help pinpoint the cause of your symptoms.

  • Magnetic resonance imaging (MRI). This scan uses a magnet and radio waves to produce a detailed 3D view of nerves and tissue.
  • Computerized tomography (CT). A CT scanner rotates around the body to take a series of images. A computer uses the image to make a detailed view of the peripheral nerve tumor. A CT scan can help your provider determine how the tumor may be affecting you.
  • Electromyogram (EMG). For this test, small needles are placed in the muscles. An instrument records the electrical activity in the muscle as they're moved.
  • Nerve conduction study. This test is often done with an EMG. It measures how fast the nerves carry electrical signals to the muscles.
  • Tumor biopsy. If you have a nerve tumor, you may need a biopsy. A small sample of cells from the tumor is removed and analyzed. Depending on the tumor's size and location, you may need to have medicine that numbs an area of the body, called local anesthesia, or medicine that puts you to sleep, called general anesthesia, during the biopsy. Sometimes a biopsy is the only way to determine whether a tumor is cancerous.
  • Nerve biopsy. A biopsy of the nerve may be needed in people who have certain conditions, such as progressive peripheral neuropathy and enlarged nerves that mimic nerve tumors.

Peripheral nerve tumors aren't common. It's important to find a provider who is experienced in diagnosing and treating them. If needed, seek a second opinion.


Schwannoma being removed


Schwannoma being removed

Surgeons carefully remove schwannomas while taking care to preserve nerve fascicles that aren't affected by the tumors. Nerve fascicles are bundles of nerve fibers.

Gamma rays delivering radiation to the head.
Gamma Knife stereotactic radiosurgery

Gamma Knife stereotactic radiosurgery

Gamma rays delivering radiation to the head.

Stereotactic radiosurgery technology uses many small gamma rays to deliver a precise dose of radiation to the target.

Treatment of a peripheral nerve tumor depends on the type of tumor, what nerves and other tissues it affects, and symptoms. Treatment options may include:


Watching and waiting to see if the tumor grows may be an option if it's in a place that makes removal difficult. Or it may be an option if the tumor is small, slow growing, and causes few or no symptoms. You'll have regular checkups and may have MRI scans, CT scans or ultrasounds done every 6 to 12 months to see if the tumor is growing. If repeat scans show that the tumor is stable, then it may be monitored every several years.


Some peripheral nerve tumors are removed with surgery. The goal of surgery is to take out the entire tumor without damaging nearby healthy tissue and nerves. When that isn't possible, surgeons remove as much of the tumor as they can.

New methods and tools allow surgeons to reach tumors that are difficult to access. High-powered microscopes used in microsurgery make it easier to tell the difference between a tumor and healthy tissue. And the function of nerves can be monitored during surgery, which helps preserve healthy tissue.

Risks of surgery include nerve damage and disability. These risks are often based on the size of the tumor, where it's located and the approach used for surgery. Some tumors also grow back.

Stereotactic radiosurgery

Stereotactic radiosurgery is used to treat some peripheral nerve tumors in or around the brain. Radiation is delivered precisely to a tumor without making an incision. One type of this kind of surgery is called Gamma Knife radiosurgery.

Risks of radiosurgery include weakness or numbness in the treated area. Or the tumor may continue to grow. Very rarely, the radiation could cause cancer in the treated area in the future.

Cancer treatment

Cancerous tumors are treated with standard cancer therapies. These include surgery, chemotherapy and radiation therapy. Early diagnosis and treatment are the most important factors for a good outcome. Tumors may come back after treatment.


After surgery, you may need physical rehabilitation. Your health care provider may use a brace or a splint to keep your arm or leg in a position that helps you to heal. Physical therapists and occupational therapists can help you recover function and mobility lost due to nerve damage or limb amputation.

Coping and support

It can be stressful to deal with the possibility of peripheral nerve tumor complications. Choosing which treatment would be best for you also can be a hard decision. These suggestions may help:

  • Learn as much as you can about peripheral nerve tumors. The more you know, the better prepared you'll be to make good choices about treatment. Besides talking to your health care provider, you may want to talk to a counselor or a social worker. Or you may find it helpful to talk to other people who've had a condition like yours. Ask about their experiences during and after treatment.
  • Maintain a strong support system. Family and friends can be a source of support. You may find the concern and understanding of other people with a condition like yours especially comforting. Your health care provider or a social worker may be able to put you in touch with a support group.

Preparing for an appointment

If your primary care provider thinks you have a peripheral nerve tumor, you'll be referred to a specialist. Specialists include doctors who are experts in disorders of the nervous system, called neurologists, and doctors trained in brain and nervous system surgery, called neurosurgeons.

What you can do

Before the appointment, you might want to prepare a list of answers to the following questions:

  • When did you first notice this problem?
  • Has it gotten worse over time?
  • Have your parents or siblings ever had similar symptoms?
  • Do you have other medical problems?
  • What medicines or supplements do you take?
  • What surgeries have you had?

What to expect from your doctor

Your doctor may ask some of the following questions:

  • Do you have pain? Where is it?
  • Do you have any weakness, numbness or tingling?
  • Have your symptoms been constant or do they come and go?
  • What treatments have you tried for these problems?