Corticobasal degeneration (corticobasal syndrome)

Description

A rare disease in which protein builds up in the brain causing nerve cell death. Often presents through symptoms called corticobasal syndrome.

Overview

Corticobasal degeneration (CBD) most often is caused by the buildup of a protein called tau in the brain cells. The buildup can cause nerve cells in the brain to break down and areas of the brain to shrink. This can lead to a collection of symptoms known as corticobasal syndrome (CBS).

Symptoms

Symptoms caused by corticobasal degeneration often are diagnosed as CBS. CBS symptoms include problems with movement, thinking, speech and behavior. Movement symptoms may be noticed more on one side of the body. Parts of the body may feel stiff, hard to move or control. The ability to speak, remember or control behavior may decline.

Treatment

There are no treatments that slow the progression of corticobasal degeneration. Symptoms tend to get worse over 6 to 8 years. Medicines may help manage symptoms. Occupational, physical or speech therapy also may help.